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Generation, High-Throughput Screening, and Biobanking of Human-Induced Pluripotent Stem Cell-Derived Cardiac Spheroids
Published on: March 10, 2023
Generation and applications of cardiac spheroids
Dana Idais1,2, Christopher D Roche3, Georgia Kalogianni2
1Cardiovascular Regeneration Group, Heart Research Institute, Sydney, NSW, Australia.
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Cardiac spheroids (CSs) offer valuable insights into the fundamental aspects of cardiac biology as they model molecular, cellular, and extracellular features typical of the myocardium. This review introduces current engineering methods for CS generation and their applications. Commonly referred to as "mini hearts", their applications include disease modelling, drug and toxicity screening, and personalised therapeutics in cardiac regenerative medicine.
