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Updated: Apr 26, 2026

In Vitro Assay to Study Tumor-macrophage Interaction
Published on: August 1, 2019
Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential
Anton Block1, Xiaoya Liu1, Daniel Zhang1
1Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Abstract:
Macrophages strongly influence cancer progression through their adaptable phenotypes and responses to mechanical and biochemical cues. Their abundance across tumors and links to poor outcomes drive interest in macrophage-targeted therapies. This review highlights macrophage mechanobiology, key behaviors, and the potential of engineered macrophages, using genetic (CAR) or non-genetic "Trojan horse" and "backpacking" strategies, to deliver therapies and reshape the immunosuppressive tumor microenvironment.
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