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Peculiarities of the Effect of Selective of α2A/D-Adrenoreceptor Blockade on the Isolated Rat Heart
L I Khisamieva1, A M Sadykov1, A L Zefirov2
1Kazan (Volga Region) Federal University, Kazan, Russia.
Abstract:
We studied ex vivo effect of α2A/D-adrenoreceptor (α2A/D-AR) antagonist RX821002 at concentrations of 10-9-10-6 M on inotropy, chronotropy, and coronary flow in Langendorff-isolated rat heart. The minimum concentration of the antagonist did not affect the studied cardiac parameters. The α2A/D-AR antagonist at the concentrations of 10-8-10-6 M increased contraction pressure of the left ventricular myocardium and coronary flow. RX821002 exerted a positive and negative chronotropic effect depending on the concentration. Application of RX821002 at a concentration of 10-7 M caused dual-effect: both an increase and a decrease in heart rate were observed. The most pronounced changes in chronotropy and inotropy were revealed after application of α2A/D-AR blocker at a concentration of 10-7 M.
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