Insights into the factors contributing to artemisinin resistance in Plasmodium falciparum
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Updated: Apr 27, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
Priyanka Sharma1, Kanika Verma1, Suchi Tyagi2
1Department of Molecular Epidemiology, Indian Council of Medical Research, National Institute of Malaria Research, Sector 8, Dwarka, New Delhi 110077, India.
Abstract:
Artemisinin (ART)-based combination therapies are instrumental in reducing the burden of malaria worldwide. However, the emergence of ART resistance (ARTR) threatens the elimination of malaria. Understanding the mechanisms regulating ARTR is essential for developing effective strategies to prevent malaria. While various mutations in the Plasmodium falciparum Kelch13 gene, particularly in the propeller domain, are linked to ARTR, data from in vitro and field-based studies indicate that additional genetic determinants and pathways, including reduced haemoglobin endocytosis, increased phosphatidylinositol-3-kinase levels, activation of unfolded protein response and polymorphism in various other genes, also contribute to the development of resistance. This narrative provides an overview of the molecular mechanisms related to ARTR.
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