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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Related Experiment Video

Updated: Apr 27, 2026

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
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Intralesional Adipose-Derived Stem Cells Reverse Established Dermal Fibrosis and Modulate Angiogenesis-Related

Eunji Lee1, Yeon Hee Ryu1, Su Jin Lee1

  • 1Department of Medical Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Tissue Engineering and Regenerative Medicine
|April 25, 2026
PubMed
Summary

Adipose-derived stem cells (ASCs) significantly reduced skin fibrosis in a systemic sclerosis mouse model. This regenerative therapy may offer a promising treatment for systemic sclerosis skin disease by improving vascular function and suppressing fibrosis.

Keywords:
Adipose-derived stem cellsAngiogenesisFibrosisLaser doppler perfusion imagingSystemic sclerosis

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Area of Science:

  • Regenerative Medicine
  • Stem Cell Therapy
  • Dermatology

Background:

  • Systemic sclerosis (SSc) causes progressive skin fibrosis and microvascular dysfunction.
  • Current therapies do not reliably reverse established fibrosis or restore perfusion.
  • The therapeutic potential of adipose-derived stem cells (ASCs) in established SSc requires further definition.

Purpose of the Study:

  • To evaluate the therapeutic efficacy of ASCs in a bleomycin-induced systemic sclerosis mouse model.
  • To investigate the impact of ASCs on dermal fibrosis and microvascular function.
  • To explore the underlying mechanisms of ASC action in a preclinical SSc setting.

Main Methods:

  • A bleomycin-induced systemic sclerosis mouse model was established.
  • Mice received intralesional injections of ASCs or vehicle on day 14.
  • Cutaneous perfusion, dermal histology, hydroxyproline content, gene expression (RT-qPCR), and immunohistochemistry were analyzed.

Main Results:

  • ASCs significantly attenuated dermal fibrosis, reducing thickness and collagen content.
  • ASC treatment suppressed key profibrotic and inflammatory gene transcripts (e.g., α-SMA, TGF-β1, TNF-α).
  • ASCs increased vascular response transcripts (e.g., VEGF, CD34) and improved perfusion.

Conclusions:

  • A single intralesional ASC injection alleviated established dermal fibrosis in an SSc model.
  • ASC therapy was associated with improved vascular parameters in fibrotic skin.
  • ASCs may act via paracrine suppression of TGF-β1-driven fibroblast activation, supporting their potential as a regenerative strategy for SSc skin disease.