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Updated: Apr 27, 2026
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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
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Visual Outcomes Following Infectious Endophthalmitis from Intravitreal Injections of Biologic Drugs: An Intelligent
Runzhi Zhang1, Isabella Tunon-Robinson2, Ashley K Nguyen3
1Statistics, Allergan, an AbbVie Company, North Chicago, IL, USA. runzhi.zhang@abbvie.com.
Ophthalmology and Therapy
|April 25, 2026
Summary
Intravitreal (IVT) injections can lead to infectious endophthalmitis, a serious complication that worsens vision. Reducing IVT injection frequency may decrease the risk of vision loss from this condition.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Ocular Infections
Background:
- Intravitreal (IVT) injections are frequent intraocular procedures globally.
- Existing evidence on post-IVT infectious endophthalmitis is limited.
- This study evaluates visual acuity outcomes following IVT biologic therapy.
Purpose of the Study:
- To assess real-world visual acuity outcomes after IVT biologic therapy.
- To elucidate the impact of post-IVT infectious endophthalmitis on patient vision.
- To analyze the relationship between IVT injection frequency and endophthalmitis incidence.
Main Methods:
- Utilized data from the Intelligent Research in Sight (IRIS) Registry.
- Included subjects receiving commercially available IVT anti-VEGF and anti-complement biologic drugs.
- Analyzed visual acuity outcomes and infectious endophthalmitis incidence.
Main Results:
- 0.052% incidence of infectious endophthalmitis per IVT injection; cumulative rate increased with more injections.
- Legally blind proportion rose from 19.4% to 46.1% after infectious endophthalmitis.
- Retinal vein occlusion and myopic choroidal neovascularization showed higher incidence rates.
Conclusions:
- Cumulative infectious endophthalmitis incidence correlates positively with IVT injection frequency.
- Visual acuity outcomes were worse post-IVT injection compared to literature values.
- Reducing IVT injection frequency may lower endophthalmitis incidence and vision loss risk.
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