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Updated: Apr 27, 2026

Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images
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Automated Brain Segmentation to Establish Reference Ranges for Regional Brain Volumes in Normally Developing Very

Marlene Hammerl1, Sophie Biermeier2, Stephanie Mangesius3,4

  • 1Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria, marlene.hammerl@i-med.ac.at.

Neonatology
|April 25, 2026
PubMed
Summary
This summary is machine-generated.

This study provides reference ranges for brain volumes in very preterm infants without brain injury. Male infants showed larger putamen and hippocampus volumes, aiding early brain development research.

Keywords:
Automated brain segmentationCerebral magnetic resonance imagingMagnetic resonance imaging biomarkersNormative dataVolumetry

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Area of Science:

  • Neuroscience
  • Pediatric Imaging
  • Developmental Biology

Background:

  • Very preterm infants often experience altered brain development.
  • Establishing normative data is crucial for identifying deviations.
  • Previous studies lacked comprehensive regional brain volume data.

Purpose of the Study:

  • To establish reference ranges for regional brain volumes in very preterm infants without brain injury at term-equivalent age.
  • To explore associations between brain volumes, sex, and gestational age.
  • To provide normative data for future research and early intervention studies.

Main Methods:

  • Cross-sectional study of 55 very preterm infants (<32 weeks GA) with normal MRI and neurodevelopmental outcomes.
  • 3-Tesla MRI scans processed using the automated Infant Free Surfer tool for 26 regional brain structures.
  • Statistical analysis included Pearson correlations and Mann-Whitney U tests to assess associations with gestational age and sex.

Main Results:

  • Reference volumes and sex-stratified centiles (3rd-97th) for 26 regional brain structures were established.
  • Male infants exhibited significantly larger putamen (p=0.031) and hippocampus (p=0.003) volumes.
  • Gestational age demonstrated weak or no correlation with regional brain volumes.

Conclusions:

  • This study provides essential normative data for regional brain volumes in a well-defined cohort of very preterm infants without brain injury.
  • These findings serve as a reference for future research on early brain development.
  • The data may aid in detecting deviations from typical brain development and informing early interventions.