From bench to byte: A UK perspective on data-driven cancer research

Cancer research is undergoing a profound transformation driven by the rapid expansion of clinical, genomic, imaging, and real-world data. As Europe prepares for the implementation of the European Health Data Space (EHDS), the ability of health systems to effectively integrate, govern, and translate these diverse datasets will shape the next era of oncology. However, technological capacity alone is insufficient; sustained impact will depend on building trust, strengthening infrastructure, and supporting the people and cultures that enable data-intensive science. Cancer Research UK (CRUK), the nation's largest cancer charity, invests over £400 million annually in research and has launched a national data strategy to accelerate progress. In partnership with CRUK, we are working to develop a more connected and collaborative cancer data science ecosystem,one that brings together researchers across disciplines, identifies shared challenges, and co-designs practical solutions to overcome them. Through the CRUK Data Science Community and its Data Interest Groups, we highlight common obstacles across health system data, data reuse, public involvement, infrastructure, and training. We also present case studies demonstrating how integrated datasets, AI-enabled analytics, international collaboration, and federated approaches are already reshaping cancer research and clinical practice. By fostering a community-led approach to trustworthy, sustainable and FAIR data access, the UK has an opportunity to unlock the full potential of data-driven research and deliver meaningful benefits for people affected by cancer.