Related Experiment Video
Updated: Apr 27, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Exploring Physical Activity and Barriers to Exercise in Transgender and Gender-Diverse Adults Initiating or
Emily Miro1,2, Masaru Teramoto3,4, Brett Toresdahl4
1St. Mark's Family Medicine Residency, Salt Lake City, UT, USA.
Background:
Little is known about physical activity and barriers to exercise in transgender and gender diverse (TGD) adults. We examined the impact of gender-affirming hormone therapy (GAHT) on exercise comfort and perceived barriers to physical activity.
Methods:
An online survey was distributed to TGD adults initiating or continuing GAHT at a primary care clinic. Comfort with exercise and agreement with statements describing potential barriers to physical activity were assessed using Likert scales. Pre- and post-GAHT comfort levels were compared using Wilcoxon signed-rank tests, and association with psychosocial variables was examined using Spearman correlations.
Results:
Among 111 participants, comfort exercising at home increased significantly after GAHT (58%-88%, P < .001), while discomfort in sports leagues increased (68%-85%). Fear of harassment or bullying was significantly associated with greater declines in comfort in public gyms (ρ = -.295, P = .006) and sports leagues (ρ = -.397, P < .001). In gender-stratified analyses, all groups reported increased comfort at home, but transgender women uniquely experienced declines in public gym (P = .002) and sports league comfort (P < .001).
Conclusions:
TGD respondents reported increased comfort exercising at home and decreased comfort exercising in sports leagues post-GAHT. Barriers included fear of acceptance, harassment, and body discomfort. Post-GAHT changes in exercise comfort appear strongly influenced by psychosocial factors and setting-specific concerns, particularly for transgender women. These findings highlight the need for safer, affirming exercise environments and targeted strategies to reduce harassment and enhance access to physical activity for TGD adults.
More Related Videos
07:27Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
07:26Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
Related Concept Videos
Physiological Barriers
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Signs of Puberty
Hormonal Regulation
Hormonal Regulation
Testosterone: Functions and Regulation