Autologous skin microfragments as a regenerative approach for chronic wound healing and burn sequelae

Chronic wounds represent a significant healthcare challenge, necessitating innovative regenerative approaches. Autologous skin micrografts (ASMs) offers a promising solution for impaired wound healing. The technique involves mechanical disaggregation of full-thickness skin punch biopsies into micrografts, which are then injected or combined with a biological scaffold to promote healing. This retrospective case series presents our center's experience treating chronic wounds and burn sequelae using ASMs. Twelve cases involving ten patients were analyzed, with indications ranging from chronic ulcers to post-burn scar contractures. Results showed accelerated skin healing, improved skin quality, and functional recovery. The mean time to healing was 25.2 days for wound closure and 69.6 days for scar improvement. The procedure's simplicity, minimal invasiveness, and applicability in complex cases with limited donor sites reinforce its clinical potential. ASMs may represent a viable regenerative therapy in advanced wound care.