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Updated: Apr 27, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
High-dose dexamethasone after Caesarean delivery: promising signal or marginal gain?
1Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, VIC, Australia; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.
Abstract:
Low-dose intravenous dexamethasone reduces postoperative pain, opioid consumption, and postoperative nausea and vomiting compared with placebo after general and spinal anaesthesia. However, evidence of additional analgesic benefit from high-dose dexamethasone remains unconvincing, and data are lacking in obstetric patients. In this issue of the British Journal of Anaesthesia, a randomised clinical trial observed only modest benefits of high-dose compared with low-dose intravenous dexamethasone after elective Caesarean delivery. Further studies targeting personalised care in patients at particular risk of severe acute postoperative pain and persistent pain are required.
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