Related Experiment Video

Updated: Apr 27, 2026

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

Assessing safety in the RTS,S/AS01 malaria vaccine implementation programme: an overview and comparison of methods

David Schellenberg¹, Mary Hamel², Patricia Njuguna³

¹London School of Hygiene and Tropical Medicine, London, UK. david.schellenberg@lshtm.ac.uk.

Malaria Journal

|April 26, 2026

Abstract:

The RTS,S/AS01 malaria vaccine implementation programme evaluated safety signals from the phase 3 trial using sentinel hospital and community-based mortality surveillance. Strengthened pharmacovigilance was used to identify rare, unanticipated signals related to vaccination. Cohort event monitoring was designed to identify rare conditions of special interest. We summarise the strengths and weaknesses of these complementary approaches to safety monitoring.

Keywords:

Malaria Pilot RTS,S/AS01E Safety assessment Vaccine

More Related Videos

Protocol for RNAi Assays in Adult Mosquitoes A. gambiae

Protocol for RNAi Assays in Adult Mosquitoes A. gambiae

Published on: July 4, 2007

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

Related Concept Videos

Pharmacovigilance

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

Articles linked to this work by shared authors, journal, and citation graph.

The Malaria Vaccine Implementation Programme reduced clinical malaria in Kenya, 2020 to 2022 : Impact evaluation with predictive time-series models of routine surveillance data.

Malaria journal·2026

Understanding the role of parental decision-making and quality of clinical care in under-5 mortality in Western Kenya: an application of the Three Delays model.

BMC health services research·2026

Post-mortem characterisation of pathogen-specific causes of infection-related deaths in African and south Asian neonates: a prospective, observational, multicentre study.

The Lancet. Infectious diseases·2026

Impact of introducing RTS,S/AS01E malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme.

Lancet (London, England)·2026

Deaths with preceding hospitalisations within 180 days in eight countries in sub-Saharan Africa and South Asia: A secondary descriptive analysis of the Child Health and Mortality Prevention Surveillance (CHAMPS) network.

BMJ open·2026

Country-specific estimates of misclassification rates of computer-coded verbal autopsy algorithms.

BMJ global health·2026

See all related articles