Hemoadsorption for refractory shock after amlodipine intoxication: a case report.

Area of Science:

• Cardiology
• Toxicology
• Nephrology

Background:

• Dihydropyridine calcium channel blockers, like amlodipine, are common antihypertensives.
• Overdoses can lead to severe cardiovascular collapse and multi-organ failure.
• Refractory cases may benefit from enhanced drug elimination strategies.

Purpose of the Study:

• To report a case of severe amlodipine poisoning.
• To evaluate the efficacy of hemoadsorption therapy in this context.

Main Methods:

• A case of intentional amlodipine overdose (150 mg) in an elderly male.
• Treatment involved intensive care, hemodynamic stabilization, and hemoadsorption using a Jafron HA230 styrene resin filter.
• Concurrent management focused on supporting vital functions.

Main Results:

• The patient presented with refractory vasoplegic shock.
• Hemoadsorption effectively cleared amlodipine from the blood.
• The patient experienced a successful clinical outcome with hemodynamic stabilization.

Conclusions:

• Hemoadsorption therapy shows promise for treating severe poisoning with protein and lipid-bound toxins.
• This case suggests a potential role for hemoadsorption in managing amlodipine toxicity.
• Further research is needed to establish standardized guidelines for hemoadsorption in drug toxicity management.