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Updated: Jul 6, 2026

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Hemoadsorption for refractory shock after amlodipine intoxication: a case report.

Leonor Boavida1, Sara Travassos2, Dulce Correia2

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|April 26, 2026
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Summary

Amlodipine overdose can cause life-threatening shock. Hemoadsorption therapy using a resin filter successfully removed the drug, aiding patient recovery in a severe poisoning case.

Keywords:
Case reportDihydropyridine calcium channel blockers toxicityHemoadsorptionOverdoseRefractory shock

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Area of Science:

  • Cardiology
  • Toxicology
  • Nephrology

Background:

  • Dihydropyridine calcium channel blockers, like amlodipine, are common antihypertensives.
  • Overdoses can lead to severe cardiovascular collapse and multi-organ failure.
  • Refractory cases may benefit from enhanced drug elimination strategies.

Purpose of the Study:

  • To report a case of severe amlodipine poisoning.
  • To evaluate the efficacy of hemoadsorption therapy in this context.

Main Methods:

  • A case of intentional amlodipine overdose (150 mg) in an elderly male.
  • Treatment involved intensive care, hemodynamic stabilization, and hemoadsorption using a Jafron HA230 styrene resin filter.
  • Concurrent management focused on supporting vital functions.

Main Results:

  • The patient presented with refractory vasoplegic shock.
  • Hemoadsorption effectively cleared amlodipine from the blood.
  • The patient experienced a successful clinical outcome with hemodynamic stabilization.

Conclusions:

  • Hemoadsorption therapy shows promise for treating severe poisoning with protein and lipid-bound toxins.
  • This case suggests a potential role for hemoadsorption in managing amlodipine toxicity.
  • Further research is needed to establish standardized guidelines for hemoadsorption in drug toxicity management.