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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

172
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
161
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

204
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
204

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Dual-Stimuli Injectable Platforms for Localized Breast Cancer Therapy.

Celia Nieto1,2, Álvaro González-Garcinuño1,2, Antonio Tabernero1,2

  • 1Department of Chemical Engineering, University of Salamanca, Plaza de los Caídos s/n, 37001 Salamanca, Spain.

Nano Letters
|April 26, 2026
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Summary

Injectable drug delivery systems that respond to pH and temperature offer new hope for treating locoregional breast cancer recurrence by targeting cancer cells more effectively. Liposome-in-hydrogel systems show particular promise for improved drug delivery and treatment outcomes.

Keywords:
breast cancerdrug delivery systeminjectable hydrogelliposomespH-responsivethermoresponsive

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • Locoregional breast cancer recurrence presents a significant therapeutic challenge due to limited drug selectivity and toxicity.
  • Current treatments often struggle to effectively target malignant cells while sparing healthy tissues.

Purpose of the Study:

  • To review the potential of pH- and temperature-responsive injectable formulations for targeted breast cancer therapy.
  • To highlight advanced platforms like smart hydrogels and hybrid liposome-in-hydrogel systems.
  • To outline essential characterization studies for clinical translation.

Main Methods:

  • Review of existing literature on stimuli-responsive drug delivery systems for cancer.
  • Discussion of design principles and synthesis strategies for pH- and temperature-responsive materials.
  • Analysis of liposome-in-hydrogel hybrid systems for enhanced therapeutic delivery.

Main Results:

  • pH- and temperature-responsive formulations demonstrate potential for preferential targeting of malignant cells.
  • Liposome-in-hydrogel hybrid systems offer advantages in drug encapsulation, stability, manufacturing, and controlled release.
  • Various advanced platforms are being explored for improved breast cancer treatment.

Conclusions:

  • Stimuli-responsive injectable drug delivery systems represent a promising strategy for overcoming challenges in treating locoregional breast cancer recurrence.
  • Liposome-in-hydrogel systems warrant further investigation for their therapeutic potential in breast cancer.
  • Comprehensive characterization is crucial for the clinical translation of these advanced materials.