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Canagliflozin Alleviates Pressure Overload-Induced Cardiac Dysfunction via PINK1 Regulation by Inhibiting

Wenjun Xiong1, Nana Xiong2, Yifan Wu2

  • 1Department of Cardiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China; Pharmaceutical Science, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.

The Canadian Journal of Cardiology
|April 26, 2026
PubMed
Summary

Canagliflozin protects the heart by inhibiting excessive mitophagy and ferroptosis, crucial processes in heart failure. This reveals a new mechanism for protecting heart cells from stress-induced damage.

Keywords:
PINK1canagliflozinferroptosisheart failuremitophagy

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