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From modular engineering to practical applications: Advances in GPCR-based yeast biosensors.
Yu Zhang1, Wenqian Liu1, Suru Wen2
1Key Laboratory of Biomass Chemical Engineering of Ministry of Education & State Key Laboratory of Biobased Transportation Fuel Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; BGI Research, Changzhou 213299, China; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou 310030, China.
Biotechnology Advances
|April 26, 2026
Summary
GPCR-based yeast biosensors leverage sensitive G protein-coupled receptors (GPCRs) and yeast
Area of Science:
- Biotechnology
- Molecular Biology
- Biosensor Technology
Background:
- G protein-coupled receptors (GPCRs) are crucial for cellular signaling and sensing.
- Yeast offers a genetically tractable platform for biosensor development.
- GPCRs' sensitivity and specificity make them ideal for biosensing applications.
Purpose of the Study:
- To systematically review engineering strategies for GPCR-based yeast biosensors.
- To analyze modifications in sensing, transduction, and output modules.
- To highlight advancements in biosensor performance and applications.
Main Methods:
- Modular framework analysis of GPCR-based yeast biosensors.
- Review of engineering strategies for GPCRs, yeast signaling, and reporter systems.
- Assessment of performance metric enhancements and application expansion.
Main Results:
- Engineering efforts have optimized GPCR-based yeast biosensors through modular modifications.
- Enhanced sensing, transduction, and reporter modules improve key performance metrics.
- These engineered biosensors are applied across diverse fields.
Conclusions:
- GPCR-based yeast biosensors represent a powerful and adaptable biosensing platform.
- Integration of AI and synthetic biology will drive future predictive and programmable biosensor design.
- Continued engineering efforts promise next-generation biosensors with enhanced capabilities.
