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In Silico Transcriptomic Analysis Suggests That Nickel Exposure Upregulates NINJ1 Expression: Implications for Lytic

Sukran Yagmur Avcioglu¹, Busra Nur Ozdemir¹, Caglar Berkel¹

¹Department of Molecular Biology and Genetics, Tokat Gaziosmanpasa University, Tokat, Türkiye.

Environmental Toxicology

|April 26, 2026

Summary

Nickel exposure increases NINJ1 (Ninjurin 1) mRNA, potentially causing cell death and inflammation. This NINJ1 involvement in nickel allergy and toxicity warrants further experimental investigation.

Keywords:

NINJ1 cell death cell lysis inflammation nickel plasma membrane rupture pyroptosis

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Area of Science:

Toxicology
Cell Biology
Immunology

Background:

Nickel (Ni) induces cell death via apoptosis and pyroptosis.
NINJ1 (Ninjurin 1) mediates plasma membrane rupture in lytic cell death.
NINJ1's role in nickel-induced cell death is unstudied.

Purpose of the Study:

Investigate NINJ1's role in nickel-induced cell death.
Analyze NINJ1 mRNA expression in nickel-exposed cells and tissues.
Hypothesize NINJ1's contribution to nickel toxicity and allergy.

Main Methods:

In silico transcriptomics analysis of public datasets.
Utilized R programming environment for data analysis.
Compared NINJ1 mRNA levels in nickel-exposed vs. control cells and skin biopsies.

Main Results:

Nickel exposure elevated NINJ1 mRNA in human PBMCs, endothelial cells, and rat liver cells.
Higher NINJ1 mRNA expression observed in nickel-allergic skin biopsies.
Computational analysis suggests increased NINJ1 expression correlates with nickel exposure.

Conclusions:

Nickel exposure upregulates NINJ1 mRNA expression.
NINJ1 may mediate plasma membrane rupture and lytic cell death in nickel toxicity.
Findings suggest NINJ1's potential role in nickel allergy and inflammation, requiring experimental validation.