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Related Experiment Video

Updated: Apr 28, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Perinatal Depression: Current Knowledge.

Mandeep Kaur1, Marsal Sanches2

  • 1Attending Psychiatrist, Department of Psychiatry, Atrium Health Behavioral Health Psychiatry & Counseling, Concord, North Carolina, USA.

Advances in Experimental Medicine and Biology
|April 26, 2026
PubMed
Summary
This summary is machine-generated.

Perinatal depression (PND) affects many women, posing risks to maternal and infant health. Understanding its unique pathophysiology and management is crucial, requiring a multidisciplinary approach beyond current FDA-approved treatments.

Keywords:
Antenatal depressionAntidepressantsBrexanoloneHormonal therapyMaternity bluesPerinatal depressionPostpartum depressionPsychoeducationReproductive psychiatryStigma

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Area of Science:

  • Reproductive psychiatry
  • Maternal mental health
  • Perinatal health

Background:

  • Perinatal depression (PND) significantly affects women during reproductive years.
  • PND poses serious risks to maternal well-being and infant development.
  • Gaps persist in understanding PND pathophysiology and management.

Purpose of the Study:

  • To review the evolution of PND concept and clinical characterization.
  • To discuss etiological factors, risk factors, and pathophysiological mechanisms of PND.
  • To highlight specific treatment needs and management strategies for PND.

Main Methods:

  • Literature review and synthesis of current knowledge on PND.
  • Discussion of pathophysiological mechanisms distinct from major depressive disorder.
  • Analysis of current treatment options, including pharmacotherapy and non-pharmacological interventions.

Main Results:

  • PND pathophysiology may differ from major depressive disorder, necessitating specific treatments.
  • Currently, only brexanolone is FDA-approved for PND; other medications are lacking.
  • Patient/family education and a multidisciplinary approach are vital for optimal PND management.

Conclusions:

  • Effective PND management requires understanding its unique mechanisms and employing tailored treatments.
  • A multidisciplinary approach, including education and timely screening, is essential.
  • Addressing transcultural factors and stigma is important for comprehensive PND care.