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Updated: Apr 28, 2026

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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
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[Basic Approach : Transsphenoidal Approach (Nasal and Sphenoid Phase)]
Shunya Hanakita1, Hirotaka Hasegawa
1Department of Neurosurgery, Saitama Medical Center, Saitama Medical University.
No Shinkei Geka. Neurological Surgery
|April 27, 2026
Summary
Endoscopic endonasal transsphenoidal surgery offers a minimally invasive approach for skull base tumors. Mastering nasal and sphenoid anatomy is crucial for safe and effective surgical execution.
Area of Science:
- Neurosurgery
- Otolaryngology
- Endoscopic Skull Base Surgery
Background:
- Endoscopic endonasal transsphenoidal surgery is a key minimally invasive technique for skull base pathologies, especially pituitary tumors.
- Technological advancements enhance visualization and navigation, enabling direct transnasal access to the skull base.
Purpose of the Study:
- To provide a comprehensive guide to the endoscopic endonasal transsphenoidal approach.
- To detail essential anatomical landmarks and surgical techniques for safe and effective skull base access.
Main Methods:
- Detailed description of nasal cavity expansion, sphenoid sinus access, and sellar floor opening.
- Emphasis on key anatomical landmarks: ethmoid sinus lamellar concept, sphenoid ostium, and carotid artery relationships.
- Guidance on mucosal incision, septal preservation, bone removal, and CSF leak prevention strategies.
Main Results:
- The approach allows safe and effective access to the sella and adjacent skull base structures.
- Enhanced intraoperative orientation and safety are achieved through understanding critical anatomical relationships.
- Standardized techniques facilitate reconstruction and minimize complications like cerebrospinal fluid leakage.
Conclusions:
- This chapter provides a foundational understanding of endoscopic endonasal transsphenoidal surgery.
- Systematic anatomical knowledge and standardized techniques are vital for surgeons transitioning to advanced skull base procedures.
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