Related Experiment Video

Updated: Apr 28, 2026

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
07:59

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

Published on: July 21, 2017

9.2K

Molecular and Cellular Mechanisms of Anti-Obesity Agents: An Integrative Review

Harmandeep Kaur1, Deepika Kaushik2, Prasad Rasane1

  • 1Department of Food Technology and Nutrition, Lovely Professional University, Phagwara, Punjab, India.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|April 27, 2026
PubMed

Insights

Genetic factors significantly influence appetite and energy balance in obesity. Key genes like Leptin (LEP) and Proopiomelanocortin (POMC) suppress appetite, while others stimulate it, highlighting complex regulatory pathways for obesity management.

Area of Science:

  • Genetics and Molecular Biology
  • Metabolic Regulation
  • Neuroendocrinology

Background:

  • Obesity is a complex metabolic disorder influenced by genetic factors affecting appetite and energy homeostasis.
  • Several key genes and their protein products are known to regulate hunger and satiety signals within the body.

Purpose of the Study:

  • To elucidate the pivotal roles of specific genes in appetite regulation and energy homeostasis.
  • To highlight the significance of these genetic mechanisms for potential obesity interventions.

Main Methods:

  • Review and synthesis of existing research on genes involved in appetite regulation.
  • Analysis of the functions of specific genes including LEP, POMC, AgRP, NPY, GHRL, BDNF, PCSK1, IGF2BP2, and MAP2K5.

Main Results:

  • Genes like Leptin (LEP) and Proopiomelanocortin (POMC) suppress appetite, while Agouti-related peptide (AgRP) and Neuropeptide Y (NPY) stimulate it.
  • Ghrelin (GHRL) promotes hunger, and Brain-derived neurotrophic factor (BDNF) has a dual role in brain and adipose tissue.
  • Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1), Insulin-like Growth Factor 2 mRNA-Binding Protein 2 (IGF2BP2), and Mitogen-Activated Protein Kinase 5 (MAP2K5) are critical for neuropeptide processing and metabolic regulation.

Conclusions:

  • The intricate interplay of these genes is crucial for maintaining energy balance.
  • Understanding these genetic mechanisms provides valuable insights for developing effective strategies for obesity prevention and management.
Keywords:
anti‐obesityappetitedysregulationenergy homeostasisgenemutations

More Related Videos

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

17.2K
Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum Clove and Cuminun cyminum Cumin on C57BL6/j Mice Fed High-Fat Diet13:09

Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum Clove and Cuminun cyminum Cumin on C57BL6/j Mice Fed High-Fat Diet

Published on: July 31, 2021

2.7K

Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
324
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
437
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.8K
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
949
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.0K