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Insights Gained From the PPMI Brain Donation Program.

Tatiana Foroud¹, Laura E A Heathers¹, Syed Bukhari²

¹Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN.

Annals of Neurology

|April 27, 2026

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This summary is machine-generated.

Centralized brain donation enhances successful postmortem tissue collection for neurological research. Neuropathology validates biomarkers and advances disease characterization, improving understanding of conditions like Parkinson's disease.

Area of Science:

Neuropathology
Biomarker Validation
Neurodegenerative Diseases

Background:

Brain autopsy provides critical insights into neurological conditions unobtainable from living subjects.
Pathology is essential for validating biomarkers of disease biology.
Postmortem tissue collection is challenging, limiting correlation with clinical and biomarker data.

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