Related Experiment Video

Updated: Apr 28, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

7.7K

Efficacy and Safety of CorVad System in Coronary Intervention for Complex High-Risk and Indicated Patients

Guofeng Gao1,2,3, Bowen Li1,2,3, Hongwei Pan4

  • 1State Key Laboratory of Cardiovascular Disease, Beijing, China.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|April 27, 2026
PubMed

Insights

The CorVad percutaneous ventricular assist system safely and effectively supports high-risk patients undergoing percutaneous coronary intervention (PCI). This novel approach improves left ventricular ejection fraction (LVEF) and shows comparable outcomes to coronary artery bypass grafting (CABG).

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) carry high risks for complex high-risk and indicated patients (CHIPs).
  • Percutaneous ventricular assist systems offer a potential alternative for CHIPs during PCI.

Purpose of the Study:

  • To evaluate the safety and efficacy of the CorVad percutaneous ventricular assist system in CHIPs undergoing PCI.
  • To assess the impact of CorVad support on major adverse cardiovascular and cerebrovascular events (MACCE) and left ventricular ejection fraction (LVEF).

Main Methods:

  • 118 CHIPs with LVEF ≤ 40% received CorVad support during elective PCI.
  • The primary endpoint was MACCE at 30 days, with a performance goal of 22.5%.
  • Outcomes were compared to historical controls who underwent CABG.

Main Results:

  • The study met its primary endpoint, with a 30-day MACCE rate of 4.2% in the intention-to-treat cohort.
  • CorVad system implantation was successful in all patients, with significant improvements in LVEF at 48 hours and 30 days post-PCI.
  • No hemolysis was observed. MACCE rates at 30 and 90 days were comparable to propensity score-matched CABG historical controls.

Conclusions:

  • The CorVad percutaneous ventricular assist system is a safe and effective option for CHIPs undergoing PCI.
  • CorVad support demonstrates favorable hemodynamic effects and comparable clinical outcomes to CABG in this high-risk population.
Abstract

Keywords:
CorVad systemcirculatory supportcomplex high‐risk and complicated patientsleft ventricular supportpercutaneous coronary interventionpercutaneous ventricular assist device

More Related Videos

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.9K
Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

2.8K

Related Concept Videos

Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
442
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
653
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
522
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
3.3K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
888
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
493