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Open-Source Multinuclear Low-Field Preclinical MRI Scanner.

Gonzalo G Rodriguez1,2, Sergey Korchak1,2, Charlotte von Petersdorff-Campen1,2

  • 1NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

NMR in Biomedicine
|April 27, 2026
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Summary
This summary is machine-generated.

Researchers developed an open-source, low-field MRI scanner for preclinical research. This multinuclear system enhances hyperpolarized agent studies by detecting various nuclei, enabling new contrast agent development and broader innovation in low-field magnetic resonance imaging.

Keywords:
hyperpolarizationlow‐fieldmultinuclear MRIopen‐sourcepreclinical

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Area of Science:

  • Medical Imaging
  • Biophysics
  • Biomedical Engineering

Background:

  • Low-field MRI (≤0.2 T) offers cost-effective, portable diagnostic solutions.
  • Current low-field scanners primarily target human studies, limiting preclinical research.
  • Hyperpolarized agents show promise for low-field MRI but require multinuclear detection (e.g., 13C, 15N).

Purpose of the Study:

  • To present an open-source, multinuclear low-field MRI scanner for hyperpolarized preclinical research.
  • To enable the development and testing of novel contrast agents tailored for low-field MRI.
  • To facilitate replication and adaptation of low-field MRI technology by the research community.

Main Methods:

  • Designed and constructed an open-source multinuclear low-field MRI scanner operating at 66 mT.
  • Enabled detection of multiple nuclei including 1H, 23Na, 13C, and 15N.
  • Provided comprehensive documentation and CAD designs for community access and adaptation.

Main Results:

  • Successfully acquired NMR spectra from 1H, 23Na, 13C, and 15N nuclei.
  • Obtained the first in vivo images using the developed low-field MRI scanner.
  • Demonstrated the system's capability for hyperpolarized preclinical research.

Conclusions:

  • The open-source multinuclear low-field MRI platform bridges a critical gap in preclinical research.
  • This versatile scanner supports rigorous in vivo testing of novel contrast agents.
  • Facilitates broader innovation in low-field MRI technology and applications.