Related Experiment Video

Updated: Apr 28, 2026

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

560

Dissociation Between Cholesteryl Ester Transfer Protein Mass and Activity in Coronary Artery Disease Patients with

Tolga Kunak1, Ayşegül Ülgen Kunak2, Adnan Abacı3

  • 1Department of Cardiology, Akdeniz University, Faculty of Medicine, Antalya, Türkiye.

Anatolian Journal of Cardiology
|April 27, 2026
PubMed

Insights

Increased cholesteryl ester transfer protein (CETP) activity, not mass, is linked to coronary artery disease (CAD) in patients with high HDL-C and LDL-C. This suggests CETP function contributes to residual cardiovascular risk.

Area of Science:

  • Cardiovascular Disease Research
  • Lipid Metabolism Studies
  • Atherosclerosis Pathophysiology

Background:

  • High-density lipoprotein cholesterol (HDL-C) is traditionally considered cardioprotective.
  • Elevated HDL-C in some coronary artery disease (CAD) patients challenges this notion.
  • Investigating HDL subclasses, apolipoproteins, and CETP in CAD with high HDL-C and LDL-C is crucial.

Purpose of the Study:

  • To explore the roles of HDL subclasses, apolipoproteins, and CETP activity/mass in CAD patients with high HDL-C and LDL-C.
  • To determine if CETP activity or mass is associated with CAD in this specific patient group.
  • To assess the relationship between CETP activity and CAD using correlation and regression analyses.

Main Methods:

  • Enrolled 35 CAD patients and 35 matched controls with high HDL-C (≥ 60 mg/dL) and LDL-C (≥ 130 mg/dL).
  • Measured CETP mass and activity, apolipoprotein A-I (ApoA-I), ApoA-II, ApoB, and HDL subclasses (HDL2, HDL3).
  • Utilized correlation analyses and multivariate logistic regression to evaluate CETP activity's association with CAD.

Main Results:

  • CETP activity was significantly higher in CAD patients versus controls (P = .007).
  • CETP mass, HDL2, and HDL3 levels did not differ between groups.
  • ApoA-I levels were paradoxically higher in CAD patients (P = .006); CETP activity independently predicted CAD (OR 2.03, P = .002).

Conclusions:

  • Increased CETP activity, not mass, is associated with CAD in patients with high HDL-C and LDL-C.
  • This suggests CETP function may contribute to residual cardiovascular risk.
  • Elevated ApoA-I and HDL dysfunction, not just quantity, are key in atheroprotection, supporting functional lipoprotein evaluation.
Abstract

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.8K
Cholesterol Efflux Assay07:54

Cholesterol Efflux Assay

Published on: March 6, 2012

29.4K

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
2.0K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
839
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
888
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
723
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.7K