Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 28, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.5K

Creating Compartmentalized Pockets for Length-Tunable Short Peptide Growth.

Lin Huang1,2, Junghye Lee2, Luoxing Xiang1,2

  • 1Department of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore.

Journal of the American Chemical Society
|April 27, 2026
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temperature-Sensitive Carbon Capture in MOFs for Energy-Efficient Flue Gas and Biogas Purification.

ACS applied materials & interfaces·2026
Same author

Upcycling Polystyrene into Hydrophobic-Shielded Adsorbents for Efficient Direct Air Capture.

ACS applied materials & interfaces·2026
Same author

Multi-dimensional deep learning-based segmentation and volumetric assessment of sphenoid sinus fluid on postmortem CT in drowning cases.

Scientific reports·2026
Same author

In Situ Encapsulation of Cationic [2]Catenane in a Stable Zirconium Metal-Organic Framework.

Journal of the American Chemical Society·2025
Same author

Developing a novel Temporal Air-quality Risk Index using LSTM autoencoder: A case study with South Korean air quality data.

The Science of the total environment·2025
Same author

Dynamic supramolecular snub cubes.

Nature·2025
Same journal

Proton-Gated Torsional Spring for Molecular Energy Storage.

Journal of the American Chemical Society·2026
Same journal

Topologically Programmed Dual-Channel Covalent Organic Frameworks Decouple Gas and Ion Fluxes for Acidic CO<sub>2</sub> Electroreduction.

Journal of the American Chemical Society·2026
Same journal

Plasmonic Re-Excitation Enables Superoxide-Mediated Ethane Conversion to Acetic Acid under Visible Light.

Journal of the American Chemical Society·2026
Same journal

Photocatalytic Controlled Halodefluorination of Perfluoroalkyl Compounds Using <i>N</i>-Arylphenothiazines.

Journal of the American Chemical Society·2026
Same journal

Photoinduced Disproportionation Enables Oxidative Addition of Aryl Iodides at a Gallium(I) Center.

Journal of the American Chemical Society·2026
Same journal

Biocatalytic C3 β-<i>O</i>-Glycosylation of Triterpenes and Sterols to Synthesize Natural and Unnatural Saponins.

Journal of the American Chemical Society·2026
See all related articles

This study introduces a metal-organic framework (MOF) as a platform for controlled peptide synthesis. This artificial system achieves tunable, length-specific peptide growth via confined ring-opening polymerization (ROP) of N-carboxyanhydride (NCA) monomers.

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomimetic Chemistry

Background:

  • Living systems regulate macromolecular synthesis in enzyme pockets.
  • Artificial nanoconfinement strategies exist but lack tunable, length-specific peptide growth.
  • Reproducing enzyme-like spatial control in synthetic systems is a key challenge.

Purpose of the Study:

  • To develop a stable metal-organic framework (MOF) platform for controlled peptide synthesis.
  • To achieve tunable and length-specific growth of short peptides using confined polymerization.
  • To explore the potential of MOFs in biomimetic catalysis and functional material design.

Main Methods:

  • Utilized a stable metal-organic framework (MOF) as a platform for N-carboxyanhydride (NCA) ring-opening polymerization (ROP).

More Related Videos

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
06:19

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis

Published on: November 22, 2024

992
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K

Related Experiment Videos

Last Updated: Apr 28, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.5K
An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
06:19

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis

Published on: November 22, 2024

992
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
  • Investigated reaction kinetics and employed Nuclear Magnetic Resonance (NMR) spectroscopy to analyze the confined oligomerization process within MOF channels.
  • Manipulated monomer size, reaction kinetics, and amino acid pre-coordination to control peptide chain length and sequence.

    • Main Results:

    • Demonstrated confined NCA-ROP within MOF channels, yielding length-selective short peptide growth.
    • Achieved significantly higher peptide loading and chain-length selectivity compared to unconfined polymerization.
    • Observed a >30-fold acceleration in NCA-ROP by pre-coordinating amino acids at Zr6 clusters.
    • Successfully synthesized sequence-specific A-(B)n peptides by selecting appropriate monomers.

    Conclusions:

    • Established a robust MOF-based platform for biomimetic peptide synthesis, mimicking natural biosynthetic machinery.
    • Advanced the understanding of confined oligomerization and polymerization kinetics within defined nanospace.
    • Provided a versatile platform for creating functional peptide-MOF materials with potential applications in catalysis.