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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Atraumatic Splenic Rupture as the Sole Manifestation of Infectious Mononucleosis: A Case Report and Literature Review

Annalisa Coppola1, Maria Apostolou2, Hugo Dario Delle Donne2

  • 1Department of General Surgery, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, ITA.

Cureus
|April 27, 2026
PubMed

Insights

Epstein-Barr virus (EBV) infection can cause spontaneous splenic rupture, even without typical mononucleosis symptoms. This case highlights EBV as a potential cause of atraumatic splenic rupture in otherwise healthy individuals.

Area of Science:

  • Internal Medicine
  • Infectious Diseases
  • Trauma Surgery

Background:

  • Atraumatic splenic rupture is a rare but serious complication.
  • Epstein-Barr virus (EBV) infection, commonly causing mononucleosis, can lead to splenic rupture.
  • Splenic rupture may occur even without classic infectious mononucleosis symptoms.
Keywords:
atraumatic splenic rupturecase reportepstein-barr virusinfectious mononucleosissplenectomy

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