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Managing Rectal Adenocarcinoma in a Radiation-Exposed Patient: A Case Report Utilizing the PROSPECT Trial Protocol
Talal Al-Assil1, John Han1, Evan Kim1
1Oncology, UCI Medical Center, Orange, USA.
Cureus
|April 27, 2026
Summary
This case study highlights a successful chemotherapy-first approach for rectal adenocarcinoma in a patient with prior pelvic radiation. This strategy avoided further radiation toxicity, achieving favorable outcomes in locally advanced rectal cancer.
Area of Science:
- Oncology
- Radiation Oncology
- Surgical Oncology
Background:
- A 76-year-old woman presented with newly diagnosed rectal adenocarcinoma.
- She had a history of stage IV cervical cancer treated with pelvic chemoradiation, leading to significant complications.
- Standard neoadjuvant chemoradiation for rectal cancer posed high toxicity risks due to prior radiation exposure.
