Roles of Cellular Neighborhoods in Lung Cancer

The occurrence and development of lung cancer (LC) involve complex interactions between various cell types in the tumor microenvironment (TME). Understanding the spatial distribution and interaction mechanisms of these cells may be the key to overcoming LC. The advancements of single-cell and spatial transcriptome techniques have promoted our understanding of cellular neighborhoods (CNs) and their functions in the pathogenesis of LC. In this review, we focus on the impact of different etiologies on LC CNs and the current research status of CNs in LC. This review may provide new insights into the molecular mechanisms of LC pathogenesis, develop more refined classification principles for LC diagnosis, and offer new perspectives for LC treatment.