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Related Concept Videos

Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Spermatogenesis01:41

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Infertility in Females01:28

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
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Disorders of the Male Reproductive System01:20

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Menopause01:28

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Updated: Apr 28, 2026

Author Spotlight: Advancing Male Infertility Research by Unraveling Sperm Metabolism and Mitochondrial Function
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Resveratrol Effects on Male Infertility.

Sina Vakili1, Amirabbas Rostami2, Sanaz Rastegar3,4

  • 1Infertility Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.

Galen Medical Journal
|April 27, 2026
PubMed
Summary
This summary is machine-generated.

Resveratrol may impact male fertility by reducing oxidative stress and inflammation. Further research is needed to clarify its effects and mechanisms on male reproductive health.

Keywords:
InflammationMale InfertilityOxidative StressResveratrolSperm

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Area of Science:

  • Reproductive Biology
  • Nutraceutical Science
  • Biochemistry

Background:

  • Male infertility is a growing concern with significant socioeconomic and psychological impacts.
  • Key factors contributing to male infertility include oxidative stress, inflammation, and lifestyle choices.
  • Resveratrol, a polyphenol, shows promise for mitigating oxidative stress and inflammation.

Purpose of the Study:

  • To review the effects of resveratrol on human male fertility.
  • To explore the mechanisms underlying resveratrol's influence on male infertility.

Main Methods:

  • Literature review of existing studies on resveratrol and male fertility.
  • Analysis of biochemical and physiological pathways involved.

Main Results:

  • Existing research on resveratrol and male fertility presents conflicting outcomes.
  • Resveratrol's potential benefits are linked to its antioxidant and anti-inflammatory properties.
  • Mechanisms of action require further elucidation.

Conclusions:

  • The precise impact of resveratrol on human male fertility is not yet definitively established.
  • Resveratrol's antioxidant and anti-inflammatory effects suggest a potential role in managing male infertility.
  • More targeted research is necessary to confirm efficacy and understand underlying mechanisms.