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Predictive 3D Modeling of Orthognathic Surgery Outcomes Using Machine Learning Algorithms: A Systematic Review :.
Masoud Hasanzade1, Ailar Yousefbeigi2, Soheil Jafari3
1Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Galen Medical Journal
|April 27, 2026
Summary
This systematic review explores machine learning in 3D modeling for predicting orthognathic surgery results. AI and digital planning are transforming maxillofacial surgery outcomes.
Area of Science:
- Maxillofacial Surgery
- Artificial Intelligence in Medicine
- 3D Modeling and Simulation
Background:
- Orthognathic surgery corrects maxillofacial deformities for functional and aesthetic purposes.
- Predicting surgical outcomes is crucial for patient care and treatment planning.
Purpose of the Study:
- To systematically review and analyze studies (2020-2025) on machine learning (ML) algorithms in 3D modeling for predicting orthognathic surgery outcomes.
- To assess the current state and trends of AI applications in this field.
Main Methods:
- Systematic review of articles published between 2021-2025 from PubMed and Google Scholar.
- Inclusion criteria: original studies, ML/deep learning for outcome prediction using 3D modeling, English language, full-text access.
- Manual checking of reference lists for comprehensive search.
Main Results:
- 12 studies were included from 42 identified articles.
- ML algorithms (deep neural networks, reinforcement learning, random forest, graph-based models) were used for outcome prediction.
- 3D facial models and CBCT images were commonly used for preoperative design and outcome prediction.
Conclusions:
- Digital technologies, including AI and 3D modeling, are increasingly vital in maxillofacial and cosmetic surgery.
- Virtual planning enhances the precision and predictability of orthognathic procedures.
- These advancements signify a transformation in surgical care for maxillofacial deformities.

