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Related Experiment Video

Updated: Apr 28, 2026

3D Imaging of PDL Collagen Fibers during Orthodontic Tooth Movement in Mandibular Murine Model
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The Interaction Between Orthodontics and Periodontal Tissue Remodeling :.

Mina Abasi1, Ali Goodarzi2, Raheleh Solhmirzaei3

  • 1School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

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|April 27, 2026
PubMed
Summary

Orthodontic tooth movement (OTM) in adults with periodontitis requires careful management. Interdisciplinary care integrating biological insights ensures periodontal stability and successful orthodontic outcomes.

Keywords:
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Area of Science:

  • Biomaterials Science
  • Orthodontics
  • Periodontology
  • Regenerative Medicine

Background:

  • Orthodontic tooth movement (OTM) involves complex biomechanical and cellular processes.
  • Periodontitis complicates OTM in adults due to reduced regeneration and altered bone dynamics.

Purpose of the Study:

  • Review the mechanobiology of OTM in healthy and periodontally compromised adults.
  • Highlight clinical implications and knowledge gaps in treating periodontally vulnerable patients.
  • Discuss the role of interdisciplinary care and emerging technologies.

Main Methods:

  • Literature review focusing on mechanobiology, cellular roles, and signaling pathways in OTM.
  • Analysis of clinical implications of orthodontic forces on periodontium.
  • Examination of regenerative procedures and biologics in OTM.

Main Results:

  • OTM involves osteoclasts, osteoblasts, fibroblasts, and signaling pathways like RANKL/OPG.
  • Force parameters and interdisciplinary coordination are crucial for compromised periodontium.
  • Knowledge gaps exist regarding optimal timing, long-term outcomes, and adult-specific data.

Conclusions:

  • Collaborative, individualized treatment integrating biological insight and clinical expertise is vital.
  • Emerging technologies offer potential for precision-based OTM in periodontally vulnerable patients.
  • Achieving periodontal stability alongside orthodontic success requires a holistic approach.