Predictive factors for mortality in acute mesenteric ischemia.

Area of Science:

• Gastroenterology
• Vascular Surgery
• Critical Care Medicine

Background:

• Acute mesenteric ischemia (AMI) presents a significant challenge due to its rarity and high mortality rate.
• Effective early risk stratification is crucial for improving patient outcomes in AMI.

Purpose of the Study:

• To identify independent predictors of in-hospital mortality in patients diagnosed with acute mesenteric ischemia.
• To develop and validate a predictive nomogram for early risk stratification of AMI patients.

Main Methods:

• Retrospective analysis of clinical data from 235 AMI patients.
• Univariate and multivariate logistic regression to identify risk factors.
• Nomogram construction and validation using ROC analysis, Hosmer-Lemeshow test, and decision curve analysis (DCA).

Main Results:

• In-hospital mortality rate was 18.7% (44/235).
• Independent predictors of mortality included advanced age, heart failure, elevated white blood cell count (WBC), and creatinine.
• The developed nomogram demonstrated good discrimination (AUC 0.849) and calibration.

Conclusions:

• The study successfully identified key risk factors for in-hospital mortality in AMI.
• A validated nomogram can aid in early identification of high-risk patients, facilitating timely interventions and optimized treatment strategies.
• Improved risk stratification may lead to better patient outcomes in acute mesenteric ischemia.