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Association Between Body Composition and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Xinrui Cao1, Guoli Shen1, Ting Sun1
1Department of Nursing, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Body composition, not just weight, impacts type 2 diabetes mellitus (T2DM) risk. Higher body fat increases T2DM risk, while leg fat may reduce it, and low muscle mass is a risk factor.
Area of Science:
- Metabolic Health
- Endocrinology
- Obesity Research
Background:
- Conventional metrics like BMI have limitations in assessing metabolic health.
- Body composition analysis offers superior insights into metabolic heterogeneity.
Purpose of the Study:
- To systematically review and meta-analyze the association between body composition indicators (fat/muscle) and type 2 diabetes mellitus (T2DM).
Main Methods:
- Systematic search of eight databases for observational studies up to July 31, 2025.
- Random/fixed-effects models used for meta-analysis; quality assessed using AHRQ and Newcastle-Ottawa scales.
Main Results:
- Increased risk of T2DM associated with higher body fat mass, trunk fat mass, visceral fat area, body fat percentage, and fat mass index.
- Lower leg fat mass linked to reduced T2DM risk.
- Reduced skeletal muscle mass index identified as a risk factor for T2DM.
Conclusions:
- T2DM risk is linked to abnormal fat/muscle mass and uneven fat distribution.
- Body composition assessment can identify high-risk individuals for personalized T2DM prevention strategies.
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