Laryngeal Sarcoidosis: A Young Patient With Aggravating Dyspnea and Cervical Lymphadenopathy

Sarcoidosis is an inflammatory disease that can affect multiple organs; however, involvement of the head and neck, particularly the larynx, remains very rare, with an incidence of around 0.6%. The present paper describes a case of laryngeal sarcoidosis in a 25-year-old patient with no medical history, presenting a rapidly progressive dyspnea and cervical lymphadenopathy. A flexible laryngoscopy revealed supraglottic edema. Biopsy demonstrated a non-necrotizing granulomatous reaction, without dysplasia or carcinoma and negative Congo red staining, confirming the diagnosis of sarcoidosis. The patient initially responded to corticosteroid therapy but experienced recurrent edema requiring hydroxychloroquine and subsequent methotrexate therapy. This case highlights the diagnostic and therapeutic challenges of supraglottic edema in a young female patient.