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Updated: Apr 28, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Long-term clinical progression of Sneddon syndrome associated with antiphospholipid syndrome
Beatriz Pires Paes1, Julia Carolina Ribeiro Batista da Silva1, Pedro Manzke de Carvalho1
1Hospital de Base do Distrito Federal, Departamento de Neurologia, Brasília DF, Brazil.
Abstract:
Sneddon syndrome (SS) is a rare neurocutaneous disorder characterized by livedo racemosa and recurrent cerebrovascular events, frequently associated with antiphospholipid syndrome (APS). We report a 10-year follow-up of a 62-year-old man diagnosed with SS and APS. Initial presentation included seizures and ischemic lesions on brain magnetic resonance imaging (MRI). Over the years, he developed progressive livedo racemosa, progression of ischemic brain lesions, and cognitive decline. This case illustrates the natural course of SS, despite adequate therapy.
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