Evaluation of the Association between Sjögren Syndrome and Thyroid Cancer Risk: A Systematic Review and Meta-analysis...

Sjögren's syndrome affects the skin, joints, lungs, kidneys, liver, and thyroid. This research was aimed to assess the association of Sjögren's syndrome with the thyroid carcinoma risk.

The present study was used a systematic review and meta-analysis method. This study searched the databases ProQuest, PubMed, Web of Science, Cochrane, and the search engine Google Scholar until July 7, 2024. The level of significance was considered as P0.05, and all data analyses were done in STATA 14 software.

A review of 11 studies revealed that Sjögren's syndrome increased the thyroid carcinoma risk in all patients (OR: 2.08, (95%CI: 1.47, 2.94)), in patients aged 40 to 49 years (OR: 1.43, (95%CI: 1.23, 1.67)), 50 to 59 years (OR: 4.65, (95%CI: 1.87, 11.58)), 60 to 69 years (OR: 1.34, (95%CI: 1.08, 1.66)) and in women ((OR:1.83, (95%CI: 1.35, 2.48). However, there was no significant association between Sjögren's syndrome and thyroid carcinoma risk in men ((OR: 1.49, (95%CI: 0.95, 2.34). Moreover, patients with Sjögren's syndrome who had a follow-up period of = 5 years ((OR: 1.68, (95%CI: 1.10, 2.54) and patients with a follow-up period of 5 years ((OR: 5.77, (95%CI: 1.97, 16.97) were at risk of thyroid cancer. Moreover, the thyroid carcinoma risk was in Europe ((OR: 3.26, (95%CI: 1.24, 8.56) and in Asia ((OR: 1.87, (95%CI: 1.27, 2.74). Primary Sjögren's syndrome also significantly increased the thyroid carcinoma risk ((OR: 2.37, (95%CI: 1.44, 3.90).

Sjögren's syndrome increased the thyroid carcinoma risk, and female gender, fifth decade of life, European race, and involvement duration of more than 5 years were the exacerbating factors.