Advanced oral drug delivery systems: Current challenges and emerging technologies
Satomi Onoue1, Kohei Yamada1, Hideyuki Sato1
1Laboratory of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Acta Pharmaceutica Sinica. B
|April 27, 2026
Summary
Oral drug delivery faces challenges with poor solubility and absorption, impacting bioavailability. Formulation strategies are advancing to enhance drug solubility, permeability, and overall oral bioavailability for better therapeutic outcomes.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Biopharmaceutics
Background:
- Oral dosage forms are preferred for non-invasiveness and patient adherence.
- Poor oral bioavailability is often caused by low drug solubility and gastrointestinal tract permeability issues.
- Overcoming these barriers is crucial for effective oral drug therapy.
Purpose of the Study:
- To review recent advancements in formulation techniques for oral drugs.
- To explore strategies for enhancing solubility, dissolution, and permeability.
- To address challenges and development aspects of oral dosage forms.
Main Methods:
- Literature review of formulation strategies.
- Analysis of techniques to improve drug solubility and permeability.
- Discussion of pharmacokinetic behavior and biopharmaceutical properties.
Main Results:
- Various formulation strategies exist to improve oral drug bioavailability.
- Understanding physicochemical and biological barriers is key to development.
- Recent advancements focus on enhancing drug absorption and stability.
Conclusions:
- Advanced formulation techniques are vital for improving oral drug efficacy.
- Addressing low solubility and permeability enhances therapeutic effectiveness.
- Continued research in oral drug delivery is essential for pharmaceutical development.
Keywords:
BioavailabilityDrug delivery systemEmulsionMicroenvironmental pH-modifierNanoparticlesOral absorptionPoorly soluble drugsSolid dispersionMore Related Videos
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