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DIOPT: the DRSC Integrative Ortholog Prediction Tool, 2026 update.

Yanhui Hu¹, Aram Comjean¹, Chenxi Gao¹

¹Department of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.

Biorxiv : the Preprint Server for Biology

|April 27, 2026

Summary

This summary is machine-generated.

The DRSC Integrative Ortholog Prediction Tool (DIOPT) helps researchers find related proteins across species. This updated tool improves functional genomics research by integrating multiple prediction methods and supporting more species.

Keywords:

DIOPT Drosophila arthropod model organisms ortholog prediction tool

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Area of Science:

Genomics
Bioinformatics
Comparative Genomics

Background:

Orthologous protein mapping is essential for cross-species research, including literature mining and data integration.
The DRSC Integrative Ortholog Prediction Tool (DIOPT) was established in 2011 to centralize ortholog predictions for model organisms.

Purpose of the Study:

To update and enhance the DIOPT platform for improved ortholog prediction and functional genomics research.
To expand the capabilities of DIOPT by increasing supported species and integrated algorithms.
To develop a specialized version of DIOPT for arthropod species.

Main Methods:

Integration of multiple ortholog prediction algorithms.
Regular updates to underlying genome annotations.
Enhancement of the web portal with new usability features.
Development of a specialized arthropod ortholog prediction tool.

Main Results:

DIOPT has been regularly updated with new genome annotations and algorithm predictions.
The platform now supports a larger number of species and incorporates more prediction algorithms.
New features have been added to the web portal to improve user experience and data exploration.
A dedicated DIOPT version for arthropods has been developed.

Conclusions:

DIOPT remains a robust and valuable resource for functional genomics, facilitating ortholog identification across diverse species.
The continuous development ensures DIOPT meets the evolving needs of researchers in comparative genomics.
The specialized arthropod tool enhances ortholog mapping for insect and related organism research.