Related Experiment Video
Updated: Apr 28, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Unraveling quantitative trait loci (QTL) overlapping epigenomic regulatory regions associated with feeding behavior
Izally Carvalho Gervásio1,2, Luiz F Brito2, Andre C Araujo3
1Department of Food Science and Technology, Luiz de Queiroz College of Agriculture (ESALQ), University of São Paulo, São Paulo, Brazil.
Introduction:
Feed behavior traits are directly linked to the sustainability of pig production. This study aimed to investigate the genetic basis of feeding behavior traits in Landrace and Yorkshire pigs, focusing on genomic regions, quantitative trait loci (QTL), candidate genes, and metabolic pathways associated with these traits.
Methods:
Genome-wide association studies (GWAS) were performed, followed by functional enrichment analyses and integrative bioinformatics approaches to identify biologically relevant genomic regions, candidate genes, and pathways associated with feeding behavior traits.
Results:
Several candidate genes and transcription factors were identified, including STAT3, STAT5A, STAT5B, RARA, SMAD4, MYC, FOXP3, SP1, NOTCH1, and RXRA. In addition, strong candidate genes such as SLC22A2, CPAMD8, and NKX2-6 were highlighted as potentially influencing feeding behavior traits.
Discussion:
These findings improve the understanding of the genomic architecture underlying feeding behavior traits and provide valuable insights for the development of more efficient breeding programs, contributing to improved animal production efficiency and welfare.
Related Concept Videos
Regulation of Food Intake
Epistasis
Epigenetic Regulation
Polygenic Traits
Polygenic Traits
Epistasis Analysis

