Related Experiment Video
Updated: Apr 28, 2026
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
Exploring the partial immunological mechanisms of hepatitis B virus reactivation in patients with hepatitis B and
Chunhua Xiao1,2, Zhenxiong Deng2, Peng Xian3
1Department of Infectious Diseases, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Objective:
To explore the immune changes caused by anti-tuberculosis treatment, especially the fluctuations of IFN-γ, and their role in HBV reactivation and related liver injury.
Method:
This was a retrospective study. Firstly, 162 patients with hepatitis B and tuberculosis co-infection (initial HBV-TB group) and 162 patients with simple hepatitis B infection (initial HBV group) who were hospitalized at the Third People's Hospital of Huizhou from June 2016 to September 2025 were consecutively included for preliminary comparison. Secondly, from the initial cohort, a baseline comparable subgroup was selected based on age, gender, and baseline levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) for immunological analysis (a total of 14 patients in the TB-HBV group and 11 patients in the HBV group).Additionally, within the HBV-TB group, according to whether they received preventive antiviral treatment, they were divided into an untreated subgroup (n=16) and a treated subgroup (n=20) to analyze the impact of treatment on prognosis.
Result:
The comparison of baseline data between the HBV-TB group and the HBV group showed that the proportion of males was higher in the HBV-TB group, and the levels of WBC, NEU, Mon and PLT were higher than those in the HBV group. However, the levels of HBsAg, HBVDNA, ALT, AST, Lym and RBC were lower than those in the HBV group (all P<0.05). Among HBV-TB patients who did not receive anti-HBV treatment, 81.25% of the patients(13 case)had HBV reactivation, and 43.75% of them (7case)had severe liver injury. The incidence of Drug-induced liver injury(DILI) and the rate of HBV reactivation in this group were both higher than those in the anti-HBV treatment group (all P<0.05). In terms of immune indicators, the counts of lymphocytes, total T cells and CD4+ T cells in the HBV-TB group were all lower than those in the HBV group, while the levels of IFN-γ and IL-6 were higher(all P<0.05).
Conclusion:
It is recommended that HBsAg screening be conducted for all tuberculosis patients before anti-tuberculosis treatment, and preventive antiviral treatment be given to individuals with positive HBsAg to reduce the risk of HBV reactivation.
Related Concept Videos
01:25Hepatitis
01:29Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:28Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:31Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
01:28Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
01:26Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...