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A poly(trisulfide) oligomer with antimicrobial activity.

Jasmine M M Pople1, Ocean E Clarke2, Romy A Dop2,3

  • 1College of Science and Engineering, Flinders University Bedford Park South Australia 5042 Australia jasmine.pople@flinders.edu.au bart.eijkelkamp@flinders.edu.au justin.chalker@flinders.edu.au.

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Researchers developed water-soluble sulfur polymers with potent antimicrobial activity against fungi like Candida and bacteria such as Staphylococcus aureus. These novel materials offer a promising new strategy to combat antimicrobial resistance in medicine and agriculture.

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Area of Science:

  • Polymer Chemistry
  • Antimicrobial Agents
  • Materials Science

Background:

  • Antimicrobial resistance is a significant global health and agricultural threat.
  • Sulfur compounds have historical antimicrobial uses, but solubility issues limit applications.
  • Novel sulfur-rich polymers show antimicrobial potential, yet most are water-insoluble.

Purpose of the Study:

  • To synthesize a water-soluble linear poly(trisulfide) for antimicrobial applications.
  • To investigate the antimicrobial efficacy and safety of the novel sulfur polymer.
  • To explore new strategies against antimicrobial resistance using sulfur-based materials.

Main Methods:

  • Photochemical ring-opening polymerization of a cyclic trisulfide monomer.
  • Deprotonation of a carboxylic acid group to achieve water solubility.
  • Antimicrobial activity testing against Candida albicans, Candida auris, and Staphylococcus aureus.
  • Mammalian cell toxicity assays.

Main Results:

  • A water-soluble linear poly(trisulfide) was successfully synthesized.
  • The poly(trisulfide) oligomers demonstrated potent antifungal activity against C. albicans and C. auris.
  • Significant antibacterial activity was observed against Staphylococcus aureus.
  • The synthesized oligomers showed no harm to mammalian cells at effective concentrations.

Conclusions:

  • Water-soluble poly(trisulfide) oligomers are effective antimicrobial agents.
  • This work presents a new class of sulfur polymers for biological applications.
  • The findings offer a novel strategy to address the challenge of antimicrobial resistance.