Related Experiment Video

Updated: Jun 20, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

34.3K

An orally administrable hydrogen-bonded organic framework (HOF)-based nanoreactor to reprogram metabolism for

Haochen Zhang1,2, Junlin Ya1,2, Jinsong Ren1,2

  • 1Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

National Science Review
|April 27, 2026
PubMed

Insights

This study developed a stable nanoreactor for oral delivery, effectively reducing aging-related metabolites and alleviating cognitive decline in aged mice.

Area of Science:

  • Biomaterials Science
  • Gerontology
  • Nanotechnology

Background:

  • Aging leads to functional decline and increased disease risk.
  • Oral drug delivery faces challenges due to gastrointestinal degradation.
  • Metabolic dysregulation is a key factor in aging.

Purpose of the Study:

  • To develop a robust oral delivery system for anti-aging therapeutics.
  • To create a nanoreactor capable of surviving the GI tract.
  • To modulate age-related metabolic pathways and mitigate aging symptoms.

Main Methods:

  • Fabrication of a hydrogen-bonded organic framework (HOF)-based nanoreactor (MAO@NADH@PB@O-HOF@PEG).
  • Testing the nanoreactor's stability in extreme conditions (ultra-acidic, boiling water).
  • Administering the nanoreactor orally to aged mice to assess its therapeutic effects.

Main Results:

  • The HOF nanoreactor demonstrated exceptional stability against GI degradation.
  • In situ catalysis within the intestine led to degradation of the aging-elevated metabolite isoamylamine (IAA).
  • Oral administration significantly alleviated cognitive decline, neuronal damage, and neuroinflammation in aged mice.

Conclusions:

  • HOF materials offer a promising platform for stable oral drug delivery systems.
  • The developed nanoreactor effectively targets age-related metabolic dysregulation.
  • This approach shows potential for developing novel geroprotective therapeutics.
Keywords:
gut metabolomehydrogen-bonded organic frameworksoral catalytic therapysenescence

More Related Videos

Induction and Validation of Cellular Senescence in Primary Human Cells08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.2K
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.9K

Related Concept Videos

Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.