Multiple Myeloma Presenting as Lower Gastrointestinal Bleeding: A Case Report.
Ahmed Arabi1, Naseem Ambra1,2, Asgad Mohamed Ahmed Eltigani2
1College of Medicine, QU Health Qatar University Doha Qatar.
Clinical Case Reports
|April 27, 2026
Summary
Multiple myeloma, a rare bone marrow cancer, can initially present as gastrointestinal bleeding and anemia. Early diagnosis and bortezomib treatment are crucial for managing this rare multiple myeloma manifestation.
Area of Science:
- Hematology
- Oncology
- Gastroenterology
Background:
- Multiple myeloma (MM) is a plasma cell neoplasm affecting bone marrow and potentially other organs.
- Gastrointestinal bleeding as an initial symptom of MM is exceptionally rare.
Purpose of the Study:
- To report a rare case of multiple myeloma presenting with gastrointestinal bleeding.
- To highlight the diagnostic challenges and successful management of such a case.
Main Methods:
- Case report of a 46-year-old male patient.
- Initial evaluation included routine endoscopy.
- Diagnosis was confirmed through hematologic and imaging investigations.
Main Results:
- The patient presented with unexplained gastrointestinal bleeding and severe anemia.
- Endoscopic evaluation was inconclusive for a GI source.
- Hematologic and imaging studies confirmed multiple myeloma.
Conclusions:
- Unexplained GI bleeding and anemia in adults warrant consideration of plasma cell dyscrasias, including multiple myeloma.
- Early diagnosis and appropriate chemotherapy, such as bortezomib-based regimens, are vital for managing this rare presentation of MM.
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