miR-652-5p Promotes Neuroinflammation and Mediates Postoperative Cognitive Dysfunction in Rats by Targeting CNTNAP2

POCD model in rats was established using isoflurane anesthesia combined with surgery and an in vitro model was constructed by stimulating BV-2 microglial cells with lipopolysaccharide (LPS). A combination of techniques, including open field test, Morris water maze test, qRT-PCR, ELISA, dual-luciferase reporter assay, and cell function recovery experiments, was employed to systematically analyze behavioral changes, cell viability, inflammatory responses, oxidative stress, and gene regulation.