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Updated: Apr 28, 2026

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Published on: November 4, 2014

Optoacoustic muscle imaging.

Lina Tan^1,2,3,4, Stefanie Meyer^5,6, Jana Zschüntzsch^5,6

¹Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen; Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, 91054 Erlangen, Germany.

Journal of Neuromuscular Diseases

|April 27, 2026

Summary

This summary is machine-generated.

Optoacoustic imaging (OAI) offers a non-invasive way to study skeletal muscle, detecting structural and functional changes. This technology shows promise for diagnosing and monitoring neuromuscular disorders.

Keywords:

molecular imaging muscle diseases muscle imaging neuromuscular disorders optoacoustic

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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

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Area of Science:

Biomedical Imaging
Musculoskeletal Research

Background:

Optoacoustic imaging (OAI) provides high-resolution visualization of biological tissues.
OAI offers unique insights into skeletal muscle composition, function, and physiology.

Purpose of the Study:

To review the principles, implementations, and applications of optoacoustic imaging in skeletal muscle.
To highlight OAI's potential in diagnosing and monitoring neuromuscular disorders.

Main Methods:

Literature search in PubMed using "Optoacoustic" OR "Photoacoustic" AND "Muscle".
Screening of relevant references, including clinical studies (over 440 patients) and preclinical studies.

Main Results:

OAI detected structural changes (fibrosis, fatty infiltration) and functional impairments (perfusion, oxygenation) in skeletal muscle.
Clinical applications focus on neuromuscular disorders and peripheral artery disease.
Preclinical studies demonstrate volumetric cardiac muscle imaging.

Conclusions:

OAI is a promising non-invasive, radiation-free modality for characterizing muscle alterations in neuromuscular diseases.
The field is rapidly advancing, with significant potential for muscle physiology research and clinical diagnosis.