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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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Cefiderocol Targeted Treatment for Multidrug-Resistant Gram-Negative Infections: An Observational Cohort Study.

Lourdes García-Carnero1, Gabriela Abelenda-Alonso1,2,3, Marc Santos-Puig4

  • 1Infectious Diseases Department, Bellvitge University Hospital, 08907 L'Hospitalet de Llobregat, Spain.

Antibiotics (Basel, Switzerland)
|April 27, 2026
PubMed
Summary
This summary is machine-generated.

Cefiderocol effectively treated multidrug-resistant Gram-negative bacterial (MDR-GNB) infections in critically ill patients, showing good clinical success and safety. This novel cephalosporin offers a valuable option for severe infections with limited alternatives.

Keywords:
Pseudomonas aeruginosaStenotrophomonas maltophiliacarbapenem-resistant Enterobacteralescefiderocolmultidrug-resistant Gram-negative bacteria

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Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Critical Care Medicine

Background:

  • Multidrug-resistant Gram-negative bacteria (MDR-GNB) pose a significant treatment challenge, especially for hospitalized and critically ill patients.
  • Limited therapeutic options exist for severe MDR-GNB infections.

Purpose of the Study:

  • To evaluate the effectiveness and safety of cefiderocol for treating MDR-GNB infections.
  • To assess clinical success, mortality, recurrence, resistance, and adverse events associated with cefiderocol treatment.

Main Methods:

  • Retrospective observational study of 80 adult patients receiving cefiderocol for ≥72 hours.
  • Primary outcome: clinical success (survival and no recurrence at 30 days).
  • Secondary outcomes: 30- and 90-day mortality, recurrence, resistance, and adverse events.

Main Results:

  • Clinical success was achieved in 67.5% of patients.
  • Common pathogens included Pseudomonas aeruginosa, Enterobacterales, and Stenotrophomonas maltophilia.
  • 30-day mortality was 27.5%, 90-day mortality was 36.5%, and 5% experienced recurrence or serious adverse events.

Conclusions:

  • Cefiderocol demonstrated favorable clinical outcomes and an acceptable safety profile in a cohort of critically ill patients.
  • The study suggests cefiderocol is a valuable therapeutic option for severe MDR-GNB infections.
  • Further research may explore its role in specific patient populations and infection types.