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Ultrasonography

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...

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Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

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Patient-Friendly Real-Time Optical Tomographic Imaging System (LOTIS) for Lupus Arthritis.

Moegammad A Bardien¹, Lara Pinar¹, Alessandro Marone¹

¹Department of Biomedical Engineering, Tandon School of Engineering, New York University, Brooklyn, NY 11201, USA.

|April 27, 2026

Summary

A new wearable device, the Lupus Optical Tomography Imaging System (LOTIS), offers real-time joint inflammation assessment for systemic lupus erythematosus (SLE) patients. LOTIS detects hemodynamic changes, distinguishing diseased joints from healthy ones for objective monitoring.

Keywords:

hemodynamic monitoring joint inflammation optical tomography systemic lupus erythematosus wearable device

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Published on: August 4, 2018

Area of Science:

Biomedical Engineering
Medical Imaging
Rheumatology

Background:

Systemic lupus erythematosus (SLE) commonly causes joint pain and stiffness.
Current methods for assessing joint inflammation in SLE lack objectivity and speed at the point of care.

Purpose of the Study:

To introduce the Lupus Optical Tomography Imaging System (LOTIS), a novel wearable near-infrared (NIR) device for real-time, 3D tomographic imaging of finger joint hemodynamics.
To address limitations of previous imaging systems, enhancing robustness, reducing noise, and improving reconstruction speed.

Main Methods:

Development of LOTIS, integrating modular optical patches with on-sensor digitization.
Implementation of a computationally efficient, non-iterative multispectral reconstruction algorithm for hemoglobin concentration mapping.
Utilizing a standardized venous-occlusion protocol in a preliminary study.

Main Results:

LOTIS successfully differentiated between SLE-affected joints and healthy controls.
SLE joints showed blunted and diffuse hemodynamic responses, unlike localized, robust responses in healthy joints.
The system provided operator-independent, real-time quantification of joint-specific hemodynamic changes.

Conclusions:

LOTIS demonstrates significant potential as a clinical tool for objective assessment and longitudinal monitoring of lupus arthritis.
The device offers a patient-friendly, rapid method for quantifying joint inflammation in systemic lupus erythematosus.
Real-time hemodynamic imaging can improve the management of joint manifestations in SLE.