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Updated: Apr 28, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
H19/miR-675 Axis Promotes Cancer Metastasis by Orchestrating EMT and MET Processes
Kekely Klouyovo1, Xuefen Le Bourhis1, Éric Adriaenssens1
1University of Lille, Faculté des Sciences et Technologies, de Lille, Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, ONCOLille Institute, 59000 Lille, France.
Abstract:
Despite substantial advances in our understanding of cancer metastasis, it remains the leading cause of mortality among cancer patients. Elucidating the molecular mechanisms that drive metastatic progression is expected to facilitate the development of more effective therapeutic strategies. Among the numerous candidates, the long non-coding RNA H19 and its derivative miR-675 have been increasingly recognized as key regulators of metastatic dissemination in cancers of diverse tissue origins. In this review, we provide an up-to-date overview of the H19/miR-675 axis in metastatic progression, with particular emphasis on its involvement in the dynamic and complementary processes of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET). We also highlight the opportunity to consider the H19/miR-675 axis as promising biomarkers and potential therapeutic targets.
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