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Related Experiment Video

Updated: Apr 28, 2026

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H19/miR-675 Axis Promotes Cancer Metastasis by Orchestrating EMT and MET Processes.

Kekely Klouyovo1, Xuefen Le Bourhis1, Éric Adriaenssens1

  • 1University of Lille, Faculté des Sciences et Technologies, de Lille, Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, ONCOLille Institute, 59000 Lille, France.

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|April 27, 2026
PubMed
Summary

The H19/miR-675 axis is crucial for cancer metastasis, regulating epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET). This axis presents potential as biomarkers and therapeutic targets for improving cancer treatment outcomes.

Keywords:
EMTH19METcancerslncRNAmiR-675

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer metastasis is a primary cause of cancer-related mortality.
  • Understanding molecular drivers of metastasis is key for developing novel therapies.
  • Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are increasingly implicated in cancer progression.

Purpose of the Study:

  • To provide an updated review of the H19/miR-675 axis in cancer metastatic progression.
  • To emphasize the role of H19/miR-675 in epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET).
  • To highlight the potential of the H19/miR-675 axis as biomarkers and therapeutic targets.

Main Methods:

  • Literature review of studies investigating H19 and miR-675 in cancer metastasis.
  • Analysis of the regulatory mechanisms of H19/miR-675 in EMT and MET.
  • Synthesis of current evidence on the clinical relevance of H19/miR-675.

Main Results:

  • The H19/miR-675 axis plays a significant role in regulating EMT and MET, key processes in metastatic dissemination.
  • H19 and its derivative miR-675 are implicated in various cancer types.
  • Evidence suggests H19/miR-675 influences multiple hallmarks of cancer progression.

Conclusions:

  • The H19/miR-675 axis is a critical regulator of cancer metastasis.
  • Targeting the H19/miR-675 axis offers potential for novel therapeutic strategies.
  • H19/miR-675 holds promise as diagnostic and prognostic biomarkers in oncology.