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Persistent Symptoms After SARS-CoV-2 Infection in a Referred Occupational Clinical Registry: Symptom Patterns and
Agnessa Kozak1, Jana Wischnat1, Corinna Rademacher2
1German Social Accident Insurance Institution for the Health and Welfare Services (BGW), D-22089 Hamburg, Germany.
Diseases (Basel, Switzerland)
|April 27, 2026
Summary
Persistent symptoms after SARS-CoV-2 infection, particularly limited physical capacity and cognitive issues, are common in occupational settings. A higher number of acute symptoms increases the risk of developing long COVID, impacting work capacity.
Area of Science:
- Occupational Health
- Infectious Diseases
- Neurology
Background:
- Persistent symptoms following SARS-CoV-2 infection (long COVID) present a significant challenge in occupational health.
- Work-related SARS-CoV-2 infections contribute to long COVID, affecting employee well-being and productivity.
Purpose of the Study:
- To characterize the persistent symptoms experienced by individuals after work-related SARS-CoV-2 infection.
- To investigate the associations between these persistent symptoms and sociodemographic and clinical factors.
Main Methods:
- A multicenter clinical registry of insured individuals with persistent symptoms 12 weeks post-infection was utilized.
- Standardized assessments were conducted at specialized occupational accident insurance clinics in Germany.
- Generalized linear mixed models were employed to analyze symptom prevalence.
Main Results:
- 1511 participants reported an average of ten persistent symptoms, most commonly limited physical capacity, concentration difficulties, dyspnea, exhaustion, and memory issues.
- A higher burden of acute symptoms (≥10) significantly increased the odds of persistent complaints (ORs 2.1–4.66).
- Hospitalization correlated with dyspnea, reinfections with exhaustion/cognitive fatigue, and wild-type infection with concentration difficulties.
Conclusions:
- Limited physical capacity and cognitive impairments are the most prevalent long COVID symptoms in occupational settings.
- A higher acute symptom burden is a strong predictor of developing persistent symptoms.
- Findings support tailored evaluations and symptom-specific management strategies for occupational disease assessment.
Keywords:
Post-COVID-Syndromehealth outcomeshealthcare and welfare personnelmulticenter studyoccupational diseasespersistent symptomsMore Related Videos
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